Evaluating the effect of Zinc Oxide nanoparticles doped with Gadolinium on dose enhancement factor by PRESAGE dosimeter

Background: New treatment modali es are developed with the aim of escala ng tumor absorbed dose and simultaneously sparing the normal structures. The use of nanotechnology in cancer treatment offers some possibili es including destroying cancer tumors with minimal damage to healthy ssues. Zinc Oxide nanopar cles (ZnO NPs) are wide band gap semiconductors and seem to have a good effect on increasing the absorbed dose of target volume especially when doped with a high Z element. The aim of this study was to evaluate the effect of ZnO NPs doped with Gadolinium (Gd) on dose enhancement factor by 6MV photon beam irradia on. Materials and Methods: Various concentra ons of ZnO NPs doped with 5% Gd were incorporated into PRESAGE composi on, the 3D chemical dosimeter. Then by using a UV-Vis spectrophotometer op cal density changes and also dose enhancement factor (DEF) were determined. Results: The results of this study showed that by incorpora ng 500, 1000, 3000 and 4000 μg/ml ZnO NPs doped with Gd into PRESAGE structure the dose enhancement factor of about 1.57, 1.69, 1.78 and 1.82 in a 15 ×15 cm 2 field size could be found, respec vely. Conclusion: The results of this study showed that ZnO NPs doped with Gd could be considered as new compound for increasing the absorbed dose.